Vampire's human memories fade, so do you think that Esme still feels the pain of losing her child, or do you think that it's been blurred with all of her other memories?
I think it is the most poignant human memory she must deal with, and I think that it still causes her great pain. The fact that she brings it up to Bella so early on tells you that it is a major factor in who she is as a vampire (like Rosalie's experience is for her). I think Bella's pregnancy was very hard for her, too, because it would have been very painful for her to watch Bella slip away like that knowing that she could do nothing to help.
By the way, my name is Kayla. Thanks for the new title and all! This is my first advancement, and I am so excited.