I actually like The Host better than Twilight, although I completely love the series as well (that's why I'm here!). I just thought The Host did a better job with real-life relationships in a fictional setting. I guess that's the point with Twilight, that the characters are NOT human and shouldn't have to always act like it. There's something raw and powerful about The Host, though, that really caught me. I think it's one of those things where they DO only have a set amount of time on earth (like Wes and Walter *cries*) and it's such a short time. Wanda and the vampires could theoretically have forever, but the rest of the humans have such a short time to live and love.
Oh, yeah, and I definitely like the fact that The Host was actually intended to be an adult novel. It's hard to find really worthwhile adult fiction that isn't completely disgusting or boring, you know what I mean? It deals with adult concepts, but it's still clean and exciting. That really pulled me in. And it says something about Stephenie's character (yes, I know she's Mormon, but I am too and I know others of our religion that are not always as....ah, morally inclined in their media choices) that she won't compromise herself to fill her novels with degrading material.
Anyway, all that aside, I read Twilight, New Moon, and Eclipse first so without them, I never would have read The Host. I love the saga, just not as much as The Host. I think they're just as beautifully written, humorous, romantic, and fantastic as The Host.